Project #139:
Risk factors for COVID-19 disease progression in immunocompromised populations

Individuals with compromised immune systems are particularly vulnerable to the effects of SARS-CoV-2, and have endured a disproportionate burden of COVID-19-related morbidity and mortality throughout the course of the pandemic. Although risk factors for severe disease in the general population have been explored in detail, few studies have focused specifically on immunocompromised individuals.

Our study aims to identify factors associated with disease progression among immunocompromised individuals infected during the Omicron wave of the pandemic. The population of interest includes immunocompromised individuals as defined by: solid organ transplant; bone marrow transplant; haematologic malignancy; primary or acquired immunosuppressive condition; recent immunosuppressive medication; or recent chemotherapy or radiotherapy.

Key risk factors of interest include vaccination status, prior infection, and clinical comorbidities, among others. A better understanding of how these factors shape the risk of severe disease in immunocompromised populations may help identify individuals who may benefit from access to emerging therapeutics and support targeted clinical trial recruitment.