OpenSAFELY

Published Papers

Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19: an OpenSAFELY cohort analysis based on two cohorts

January 2021. Working on behald of NHS England, this paper used the OpenSAFELY platform to assess the association between routinely prescribed non-steroidal anti-inflammatory drugs (NSAIDs) and deaths from COVID-19.

How to Cite: Wong AY, MacKenna B, Morton CE, et alUse of non-steroidal anti-inflammatory drugs and risk of death from COVID-19: an OpenSAFELY cohort analysis based on two cohortsAnnals of the Rheumatic Diseases Published Online First: 21 January 2021. doi: 10.1136/annrheumdis-2020-219517

HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

December 2020. Working on behalf of NHS England, this paper used the OpenSAFELY platform to investigate the association between HIV infection and COVID-19 mortality.

How to Cite: Bhaskaran, K., Rentsch, C., MacKenna, B., Schultze, A., Mehrkar, A., Bates, C., Eggo, R., et al. ‘HIV Infection and COVID-19 Death: A Population-Based Cohort Analysis of UK Primary Care Data and Linked National Death Registrations within the OpenSAFELY Platform’. The Lancet HIV, December 2020, S2352301820303052. https://doi.org/10.1016/S2352-3018(20)30305-2.

Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform

November 2020. Working on behalf of NHS England, this paper used the OpenSAFELY platform to investigate the effectiveness of hydroxychloroquine for prevention, as opposed to treatment, of COVID-19 mortality. We found no evidence of benefit or harm after adjusting for important differences between people with the same health conditions prescribed hydroxychloroquine or not.

How to Cite: Rentsch CT, DeVito NJ, MacKenna B, Morton CE, Bhaskaran K, Brown JP, et al. Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality: a population-based cohort study in patients with rheumatoid arthritis or systemic lupus erythematosus using the OpenSAFELY platform. Lancet Rheumatology (2020) DOI: 10.1016/S2665-9913(20)30378-7

Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform

September 2020. Working on behalf of NHS England, this paper used the OpenSAFELY platform to investigate the association between ICS and COVID-19-related death among people with COPD or asthma using linked electronic health records (EHRs) in England, UK.

How to Cite: Schultze, Anna, Alex J Walker, Brian MacKenna, Caroline E Morton, Krishnan Bhaskaran, Jeremy P Brown, Christopher T Rentsch, et al. ‘Risk of COVID-19-Related Death among Patients with Chronic Obstructive Pulmonary Disease or Asthma Prescribed Inhaled Corticosteroids: An Observational Cohort Study Using the OpenSAFELY Platform’. The Lancet Respiratory Medicine. Accessed 9 October 2020. https://doi.org/10.1016/S2213-2600(20)30415-X.

OpenSAFELY: factors associated with COVID-19 death in 17 million patients

July 2020. Working on behalf of NHS England, this paper used the OpenSAFELY platform to quantify a range of clinical risk factors for COVID-19-related death in the largest cohort study conducted by any country to date.

How to Cite: Williamson, E.J., Walker, A.J., Bhaskaran, K. et al. OpenSAFELY: factors associated with COVID-19 death in 17 million patients. Nature (2020). https://doi.org/10.1038/s41586-020-2521-4

Pre-Prints

Trends, regional variation, and clinical characteristics of COVID-19 vaccine recipients: a retrospective cohort study in 23.4 million patients using OpenSAFELY

January 2021. Working on behalf of NHS England, this study used the OpenSAFELY platform to develop a framework for detailed near-real-time monitoring of COVID-19 vaccine roll-out; to describe trends and variation in coverage by geographic area, and between key clinical and demographic patient groups.

Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

January 2021. Working on behalf of NHS England, this study investigates how specific factors are differentially associated with COVID-19 mortality as compared to mortality from other causes.

OpenSAFELY: impact of national guidance on switching from warfarin to direct oral anticoagulants (DOACs) in early phase of COVID-19 pandemic in England

December 2020. Working on behalf of NHS England, this study investigates which people were switched from warfarin to DOACs following national guidance during the first wave of the COVID-19 pandemic; seeks to identify potentially unsafe co-prescribing of anticoagulants; and assesses whether abnormal clotting results have become more frequent during the pandemic.

Association between living with children and outcomes from COVID-19: an OpenSAFELY cohort study of 12 million adults in England

November 2020. Working on behalf of NHS England, this study investigates whether risk of infection with SARs-CoV-2 and severe outcomes differed between adults living with and without children

Study protocol: Comparison of different risk prediction modelling approaches for COVID-19 related death using the OpenSAFELY platform

October 2020. This protocol reports details of a planned study to explore the extent to which incorporating time-varying measures of infection burden over time improves the quality of risk prediction models for COVID-19 death in a large population of adult patients in England.

Ethnic differences in COVID-19 infection, hospitalisation, and mortality: an OpenSAFELY analysis of 17 million adults in England

September 2020. Working on behalf of NHS England, the aim of this study was to identify ethnic differences in the risk of COVID-19 infection, hospitalisation and mortality using a large general population cohort in England.

Supplemental Research

Post-publications supplement to Williamson, E.J., Walker, A.J., Bhaskaran, K. et al. OpenSAFELY: factors associated with COVID-19 death in 17 million patients. Nature (2020). https://doi.org/10.1038/s41586-020-2521-4

August 2020. In the above paper, working on behalf of NHS England, we estimated associations between a wide range of individual-level factors including demographics and comorbidities, and risk of COVID-19 death, but we did not explore interactions between variables. It is plausible that associations may depend on age, and evaluating this would inform more accurate risk prediction. The purpose of this supplement is therefore to present associations between individual-level factors and COVID-19 death,stratified by age group.

Download the supplement here.